Galectin 3 and incident atrial fibrillation in the community.

ABSTRACT:

Background

Galectin 3 (Gal-3) is a potential mediator of cardiac fibrosis, and Gal-3 concentrations predict incident heart failure. The same mechanisms that lead to cardiac fibrosis in heart failure may influence development of atrial fibrosis and atrial fibrillation (AF). We examined the association of Gal-3 and incident AF in the community.

Methods

Plasma Gal-3 concentrations were measured in 3,306 participants of the Framingham Offspring cohort who attended the sixth examination cycle (1995-1998, mean age 58 years, 54% women). Cox proportional hazards regression models were used to assess the association of baseline Gal-3 concentrations and incident AF.

Results

Over a median follow-up period of 10 years, 250 participants developed incident AF. Crude incidence rates

SUBMITTER: Ho JE 

PROVIDER: S-EPMC4007212 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature