Early blood biomarkers predict organ injury and resource utilization following complex cardiac surgery.

ABSTRACT:

Background

Patients undergoing complex cardiac surgery (thoracic aorta and valve) are at risk for organ failure and increased resource utilization. Neutrophil gelatinase-associated lipocalin (NGAL) has been found to be an early biomarker for renal injury. Multiplex cytokine immunoassays allow the evaluation of the early inflammatory response. We examined the relationship between early biomarker appearance (NGAL and multiplex cytokines) and organ injury and resource utilization.

Materials and methods

NGAL and multiplex cytokine immunoassays were performed at baseline, 1, 6, and 24 h following surgery on 38 patients undergoing thoracic aorta and valve operations. The mean age was 65 y with 26 males and 12 females. Acute kidney injury (AKIN definition), pulmonary failure (>24 h

SUBMITTER: Kim T 

PROVIDER: S-EPMC4007483 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature