Comparative analysis of resistant and susceptible macrophage gene expression response to Leishmania major parasite.

ABSTRACT:

Background

Leishmania are obligated intracellular pathogens that replicate almost exclusively in macrophages. The outcome of infection depends largely on parasite pathogenicity and virulence but also on the activation status and genetic background of macrophages. Animal models are essential for a better understanding of pathogenesis of different microbes including Leishmania.

Results

Here we compared the transcriptional signatures of resistant (C57BL/6) and susceptible (BALB/c) mouse bone marrow-derived macrophages in response to Leishmania major (L. major) promastigotes infection.Microarray results were first analyzed for significant pathways using the Kyoto Encylopedia of Genes and Genomes (KEGG) database. The analysis revealed that a large set of the shared genes is invol

SUBMITTER: Rabhi I 

PROVIDER: S-EPMC4007596 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature