Genetic heterogeneity of hepatitis C virus cell entry receptors seems to have no influence on selection of virus variants.

ABSTRACT:

Background

No information is available on the possible influence of the genetic heterogeneity of major hepatitis C virus (HCV) cell receptors on selection of virus variants.

Findings

Anti-D globulin preparations contaminated with the HCV strain AD78 caused hepatitis C infection in more than 3000 women in East Germany in 1978. Analysis of the core to NS2 gene sequences of this strain in several globulin batches revealed the presence of three closely related but distinct virus variants of the same strain. Apparently even distribution of these three virus variants was observed in 91 patients infected with the AD78 strain. None of these patients was infected with more than one virus variant, suggesting a selection mechanism of a particular virus variant in each patient. To verif

SUBMITTER: Lipskoch M 

PROVIDER: S-EPMC4007597 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature