Transcriptome analysis of the bloodstream stage from the parasite Trypanosoma vivax.

ABSTRACT:

Background

Trypanosoma vivax is the earliest branching African trypanosome. This crucial phylogenetic position makes T. vivax a fascinating model to tackle fundamental questions concerning the origin and evolution of several features that characterize African trypanosomes, such as the Variant Surface Glycoproteins (VSGs) upon which antibody clearing and antigenic variation are based. Other features like gene content and trans-splicing patterns are worth analyzing in this species for comparative purposes.

Results

We present a RNA-seq analysis of the bloodstream stage of T. vivax from data obtained using two complementary sequencing technologies (454 Titanium and Illumina). Assembly of 454 reads yielded 13385 contigs corresponding to proteins coding genes (7800 of which were i

SUBMITTER: Greif G 

PROVIDER: S-EPMC4007602 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature