Chemical genetics of rapamycin-insensitive TORC2 in S. cerevisiae.

ABSTRACT: Current approaches for identifying synergistic targets use cell culture models to see if the combined effect of clinically available drugs is better than predicted by their individual efficacy. New techniques are needed to systematically and rationally identify targets and pathways that may be synergistic targets. Here, we created a tool to screen and identify molecular targets that may synergize with new inhibitors of target of rapamycin (TOR), a conserved protein that is a major integrator of cell proliferation signals in the nutrient-signaling pathway. Although clinical results from TOR complex 1 (TORC1)-specific inhibition using rapamycin analogs have been disappointing, trials using inhibitors that also target TORC2 have been promising. To understand this increased therapeutic efficac

SUBMITTER: Kliegman JI 

PROVIDER: S-EPMC4007695 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature