Compositional patterns in the genomes of unicellular eukaryotes.

ABSTRACT:

Background

The genomes of multicellular eukaryotes are compartmentalized in mosaics of isochores, large and fairly homogeneous stretches of DNA that belong to a small number of families characterized by different average GC levels, by different gene concentration (that increase with GC), different chromatin structures, different replication timing in the cell cycle, and other different properties. A question raised by these basic results concerns how far back in evolution the compartmentalized organization of the eukaryotic genomes arose.

Results

In the present work we approached this problem by studying the compositional organization of the genomes from the unicellular eukaryotes for which full sequences are available, the sample used being representative. The average GC le

SUBMITTER: Costantini M 

PROVIDER: S-EPMC4007698 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature