Identification of candidate miRNA biomarkers from miRNA regulatory network with application to prostate cancer.

ABSTRACT:

Background

MicroRNAs (miRNAs) are a class of non-coding regulatory RNAs approximately 22 nucleotides in length that play a role in a wide range of biological processes. Abnormal miRNA function has been implicated in various human cancers including prostate cancer (PCa). Altered miRNA expression may serve as a biomarker for cancer diagnosis and treatment. However, limited data are available on the role of cancer-specific miRNAs. Integrative computational bioinformatics approaches are effective for the detection of potential outlier miRNAs in cancer.

Methods

The human miRNA-mRNA target network was reconstructed by integrating multiple miRNA-mRNA interaction datasets. Paired miRNA and mRNA expression profiling data in PCa versus benign prostate tissue samples were used as anoth

SUBMITTER: Zhang W 

PROVIDER: S-EPMC4007708 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature