Reactive intermediates: molecular and MS-based approaches to assess the functional significance of chemical-protein adducts.

ABSTRACT: Biologically reactive intermediates formed as endogenous products of various metabolic processes are considered important factors in a variety of human diseases, including Parkinson's disease and other neurological disorders, diabetes and complications thereof, and other inflammatory-associated diseases. Chemical-induced toxicities are also frequently mediated via the bioactivation of relatively stable organic molecules to reactive electrophilic metabolites. Indeed, chemical-induced toxicities have long been known to be associated with the ability of electrophilic metabolites to react with a variety of targets within the cell, including their covalent adduction to nucleophilic residues in proteins, and nucleotides within DNA. Although we possess considerable knowledge of the various bioche

SUBMITTER: Monks TJ 

PROVIDER: S-EPMC4007760 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature