An integrative modeling framework reveals plasticity of TGF-β signaling.

ABSTRACT:

Background

The TGF-β transforming growth factor is the most pleiotropic cytokine controlling a broad range of cellular responses that include proliferation, differentiation and apoptosis. The context-dependent multifunctional nature of TGF-β is associated with complex signaling pathways. Differential models describe the dynamics of the TGF-β canonical pathway, but modeling the non-canonical networks constitutes a major challenge. Here, we propose a qualitative approach to explore all TGF-β-dependent signaling pathways.

Results

Using a new formalism, CADBIOM, which is based on guarded transitions and includes temporal parameters, we have built the first discrete model of TGF-β signaling networks by automatically integrating the 137 human signaling maps from the Pathway Intera

SUBMITTER: Andrieux G 

PROVIDER: S-EPMC4007780 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature