Polymorphisms in the HOXD4 gene are not associated with peak bone mineral density in Chinese nuclear families.

ABSTRACT:

Aim

To determine the associations between HOXD4 gene polymorphisms with peak bone mineral density (BMD) throughing measuring three tagging single nucleotide polymorphisms (tagSNPs), including rs1867863, rs13418078, and rs4972504, in HOXD4.

Methods

Four hundred Chinese nuclear families with male offspring (1215 subjects) and 401 Chinese nuclear families with female offspring (1260 subjects) were recruited. BMD of the lumbar spine 1-4 (L1-4) and left proximal femur including total hip and femoral neck were measured by dual-energy X-ray absorptiometry. The quantitative transmission disequilibrium test (QTDT) was performed to investigate the association among the tagging SNPs, haplotypes and peak BMD.

Results

Only the CC genotype was identified in rs13418078 in the Chines

SUBMITTER: Zhang H 

PROVIDER: S-EPMC4007810 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature