Modelling the relationship between the WOMAC Osteoarthritis Index and EQ-5D.

ABSTRACT:

Objective

Economic evaluation typically is conducted using health state utilities to estimate treatment benefits. However, such outcomes are often missing from studies of clinical effectiveness. This study aims to bridge that gap by providing appropriate methods to link values from the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) to the EQ-5D utility instrument.

Method

Patients from a large registry of Spanish patients (n = 7072 observations) with knee or hip osteoarthritis who completed both WOMAC and EQ-5D was used. A mixture model approach was used based on distributions bespoke to the EQ-5D UK value set to estimate EQ-5D as a function of WOMAC pain, stiffness and function subscores.

Results

A five class mixture model provides very close f

SUBMITTER: Wailoo A 

PROVIDER: S-EPMC4007823 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature