Discovery of a Potent and Orally Bioavailable CCR2 and CCR5 Dual Antagonist

ABSTRACT: This report describes the discovery of a potent, orally bioavailable CC chemokine receptor 2 (CCR2) antagonist which, while optimized for CCR2 potency, also had potent CC chemokine receptor 5 (CCR5) activity.

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PROVIDER: S-EPMC4007850 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature