Ontology highlight
ABSTRACT:
SUBMITTER: Dosselli R
PROVIDER: S-EPMC4007951 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Dosselli Ryan R Gobbo Marina M Bolognini Erika E Campestrini Sandro S Reddi Elena E
ACS medicinal chemistry letters 20100201 1
The conjugation of the cationic antimicrobial peptide, apidaecin Ib, to the anionic photosensitizer, 5(4'-carboxyphenyl)-10,15,20-triphenylporphyrin (cTPP), afforded a new antibacterial agent effective, under light activation, against both Gram-positive and Gram-negative bacteria. At low concentrations (1.5-15 μM) the conjugate was able to reduce the survival of Escherichia coli cells by 3-4 log10, and most notably, it resulted photoactive also against hard-to-treat Pseudomonas aeruginosa, altho ...[more]