Anemia and associated clinical outcomes in patients with heart failure due to reduced left ventricular systolic function.

ABSTRACT:

Background

Anemia is associated with decreased functional capacity, reduced quality of life, and worsened outcomes among patients with heart failure (HF) due to reduced left ventricular ejection fraction (HFREF). We sought to evaluate the independent effect of anemia on clinical outcomes among those with HFREF.

Hypothesis

Anemia is associated with cardiovascular events in patients with heart failure.

Methods

The HF-ACTION trial was a prospective, randomized trial of exercise therapy vs usual care in 2331 patients with HFREF. Patients with New York Heart Association class II to IV HF and left ventricular ejection fractions of ≤ 35% were recruited. Hemoglobin (Hb) was measured up to 1 year prior to entry and was stratified by quintile. Anemia was defined as baseline Hb

SUBMITTER: McCullough PA 

PROVIDER: S-EPMC4008125 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature