Global regulatory architecture of human, mouse and rat tissue transcriptomes.

ABSTRACT:

Background

Predicting molecular responses in human by extrapolating results from model organisms requires a precise understanding of the architecture and regulation of biological mechanisms across species.

Results

Here, we present a large-scale comparative analysis of organ and tissue transcriptomes involving the three mammalian species human, mouse and rat. To this end, we created a unique, highly standardized compendium of tissue expression. Representative tissue specific datasets were aggregated from more than 33,900 Affymetrix expression microarrays. For each organism, we created two expression datasets covering over 55 distinct tissue types with curated data from two independent microarray platforms. Principal component analysis (PCA) revealed that the tissue-specific a

SUBMITTER: Prasad A 

PROVIDER: S-EPMC4008137 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature