A genome-wide association study demonstrates significant genetic variation for fracture risk in Thoroughbred racehorses.

ABSTRACT:

Background

Thoroughbred racehorses are subject to non-traumatic distal limb bone fractures that occur during racing and exercise. Susceptibility to fracture may be due to underlying disturbances in bone metabolism which have a genetic cause. Fracture risk has been shown to be heritable in several species but this study is the first genetic analysis of fracture risk in the horse.

Results

Fracture cases (n = 269) were horses that sustained catastrophic distal limb fractures while racing on UK racecourses, necessitating euthanasia. Control horses (n = 253) were over 4 years of age, were racing during the same time period as the cases, and had no history of fracture at the time the study was carried out. The horses sampled were bred for both flat and National Hunt (NH) jump raci

SUBMITTER: Blott SC 

PROVIDER: S-EPMC4008154 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature