Altered resting-state functional connectivity of striatal-thalamic circuit in bipolar disorder.

ABSTRACT: Bipolar disorder is characterized by internally affective fluctuations. The abnormality of inherently mental state can be assessed using resting-state fMRI data without producing task-induced biases. In this study, we hypothesized that the resting-state connectivity related to the frontal, striatal, and thalamic regions, which were associated with mood regulations and cognitive functions, can be altered for bipolar disorder. We used the Pearson's correlation coefficients to estimate functional connectivity followed by the hierarchical modular analysis to categorize the resting-state functional regions of interest (ROIs). The selected functional connectivities associated with the striatal-thalamic circuit and default mode network (DMN) were compared between bipolar patients and healthy cont

SUBMITTER: Teng S 

PROVIDER: S-EPMC4008631 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature