Vitamin D supplementation for depressive symptoms: a systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Objective

The aim of this study was to review the effects of vitamin D supplementation on depressive symptoms in randomized controlled trials. Although low vitamin D levels have been observationally associated with depressive symptoms, the effect of vitamin D supplementation as an antidepressant remains uncertain.

Methods

MEDLINE, CINAHL, AMED, PsycINFO, Scopus, The Cochrane Library, and references of included reports (through May 2013) were searched. Two independent reviewers identified and extracted data from randomized trials that compared the effect of vitamin D supplementation on depressive symptoms to a control condition. Two additional reviewers assessed study quality using The Cochrane Risk of Bias Tool. Seven trials (3191 participants) were included.

Results

SUBMITTER: Shaffer JA 

PROVIDER: S-EPMC4008710 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature