Increases in insulin sensitivity among obese youth are associated with gene expression changes in whole blood.

ABSTRACT:

Objective

Lifestyle intervention can improve insulin sensitivity in obese youth, yet few studies have examined the molecular signatures associated with these improvements. Therefore, the purpose of this study was to explore gene expression changes in whole blood that are associated with intervention-induced improvements in insulin sensitivity.

Methods

Fifteen (7M/8F) overweight/obese (BMI percentile = 96.3 ± 1.1) Latino adolescents (15.0 ± 0.9 years) completed a 12-week lifestyle intervention that included weekly nutrition education and 180 minutes of moderate-vigorous exercise per week. Insulin sensitivity was estimated by an oral glucose tolerance test and the Matsuda Index. Global microarray analysis profiling from whole blood was performed to examine changes in gene expr

SUBMITTER: Miranda DN 

PROVIDER: S-EPMC4008712 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature