Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a TRPP2 (polycystin-2)-dependent manner.

ABSTRACT:

Background and purpose

Identifying and characterizing potential new therapeutic agents to target cell proliferation may provide improved treatments for neoplastic disorders such as cancer and polycystic diseases.

Experimental approach

We used the simple, tractable biomedical model Dictyostelium to investigate the molecular mechanism of naringenin, a dietary flavonoid with antiproliferative and chemopreventive actions in vitro and in animal models of carcinogenesis. We then translated these results to a mammalian kidney model, Madin-Darby canine kidney (MDCK) tubule cells, grown in culture and as cysts in a collagen matrix.

Key results

Naringenin inhibited Dictyostelium growth, but not development. Screening of a library of random gene knockout mutants identified a mut

SUBMITTER: Waheed A 

PROVIDER: S-EPMC4009007 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature