Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese.

ABSTRACT:

Objectives

This study sought to identify nonredundant atrial fibrillation (AF) genetic susceptibility signals and examine their cumulative relations with AF risk.

Background

AF-associated loci span broad genomic regions that may contain multiple susceptibility signals. Whether multiple signals exist at AF loci has not been systematically explored.

Methods

We performed association testing conditioned on the most significant, independently associated genetic markers at 9 established AF loci using 2 complementary techniques in 64,683 individuals of European ancestry (3,869 incident and 3,302 prevalent AF cases). Genetic risk scores were created and tested for association with AF in Europeans and an independent sample of 11,309 individuals of Japanese ancestry (7,916 prev

SUBMITTER: Lubitz SA 

PROVIDER: S-EPMC4009240 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature