Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch.

ABSTRACT: Prostate cancer is the most commonly diagnosed malignancy among men in industrialized countries, accounting for the second leading cause of cancer-related deaths. Although we now know that the androgen receptor (AR) is important for progression to the deadly advanced stages of the disease, it is poorly understood what AR-regulated processes drive this pathology. Here we demonstrate that AR regulates prostate cancer cell growth via the metabolic sensor 5'-AMP-activated protein kinase (AMPK), a kinase that classically regulates cellular energy homeostasis. In patients, activation of AMPK correlated with prostate cancer progression. Using a combination of radiolabeled assays and emerging metabolomic approaches, we also show that prostate cancer cells respond to androgen treatment by increasin

SUBMITTER: Tennakoon JB 

PROVIDER: S-EPMC4009392 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature