Clinical correlates of serum pigment epithelium-derived factor in type 2 diabetes patients.

ABSTRACT:

Aim

To determine if serum pigment epithelium-derived factor (PEDF) levels in Type 2 diabetes are related to vascular risk factors and renal function.

Methods

PEDF was quantified by ELISA in a cross-sectional study of 857 male Veterans Affairs Diabetes Trial (VADT) subjects, and associations with cardiovascular risk factors and renal function were determined. In a subset (n=246) in whom serum was obtained early in the VADT (2.0±0.3 years post-randomization), PEDF was related to longitudinal changes in renal function over 3.1 years.

Results

Cross-sectional study: In multivariate regression models, PEDF was positively associated with serum triglycerides, waist-to-hip ratio, serum creatinine, use of ACE inhibitors or angiotensin receptor blockers, and use of lipid-lowerin

SUBMITTER: Jenkins AJ 

PROVIDER: S-EPMC4009500 | biostudies-literature | 2014 May-Jun

REPOSITORIES: biostudies-literature