Scaling brain size, keeping timing: evolutionary preservation of brain rhythms.

ABSTRACT: Despite the several-thousand-fold increase of brain volume during the course of mammalian evolution, the hierarchy of brain oscillations remains remarkably preserved, allowing for multiple-time-scale communication within and across neuronal networks at approximately the same speed, irrespective of brain size. Deployment of large-diameter axons of long-range neurons could be a key factor in the preserved time management in growing brains. We discuss the consequences of such preserved network constellation in mental disease, drug discovery, and interventional therapies.

SUBMITTER: Buzsaki G 

PROVIDER: S-EPMC4009705 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature