Rab11 regulates planar polarity and migratory behavior of multiciliated cells in Xenopus embryonic epidermis.

ABSTRACT:

Background

Xenopus embryonic skin is composed of the superficial layer with defined apicobasal polarity and the inner layer lacking the apical domain. Multiciliated cells (MCCs) originate in the inner layer of the epidermal ectoderm and subsequently migrate to the surface. How MCCs acquire the apicobasal polarity and intercalate into the superficial layer during neurulation is largely unknown. As Rab11-dependent vesicle trafficking has been implicated in ciliary membrane assembly and in apical domain formation in epithelial cells, we assessed the involvement of Rab11 in MCC development.

Results

Here we report that Rab11 is specifically enriched and becomes apically polarized in skin MCCs. Interference with Rab11 function by overexpression of a dominant negative mutant or inj

SUBMITTER: Kim K 

PROVIDER: S-EPMC4009926 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature