AlzPlatform: an Alzheimer's disease domain-specific chemogenomics knowledgebase for polypharmacology and target identification research.

ABSTRACT: Alzheimer's disease (AD) is one of the most complicated progressive neurodegeneration diseases that involve many genes, proteins, and their complex interactions. No effective medicines or treatments are available yet to stop or reverse the progression of the disease due to its polygenic nature. To facilitate discovery of new AD drugs and better understand the AD neurosignaling pathways involved, we have constructed an Alzheimer's disease domain-specific chemogenomics knowledgebase, AlzPlatform (www.cbligand.org/AD/ ) with cloud computing and sourcing functions. AlzPlatform is implemented with powerful computational algorithms, including our established TargetHunter, HTDocking, and BBB Predictor for target identification and polypharmacology analysis for AD research. The platform has assemb

SUBMITTER: Liu H 

PROVIDER: S-EPMC4010297 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature