The SLE transcriptome exhibits evidence of chronic endotoxin exposure and has widespread dysregulation of non-coding and coding RNAs.

ABSTRACT:

Background

Gene expression studies of peripheral blood mononuclear cells from patients with systemic lupus erythematosus (SLE) have demonstrated a type I interferon signature and increased expression of inflammatory cytokine genes. Studies of patients with Aicardi Goutières syndrome, commonly cited as a single gene model for SLE, have suggested that accumulation of non-coding RNAs may drive some of the pathologic gene expression, however, no RNA sequencing studies of SLE patients have been performed. This study was designed to define altered expression of coding and non-coding RNAs and to detect globally altered RNA processing in SLE.

Methods

Purified monocytes from eight healthy age/gender matched controls and nine SLE patients (with low-moderate disease activity and lack o

SUBMITTER: Shi L 

PROVIDER: S-EPMC4010412 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature