Coffee consumption in NAFLD patients with lower insulin resistance is associated with lower risk of severe fibrosis.

ABSTRACT:

Background & aims

Coffee has inverse relationships with both type 2 diabetes and hepatic fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). Relationships were explored between coffee intake and insulin resistance (IR) with respect to NAFLD histologic severity.

Methods

We analyzed data from 782 adults (≥18 years) in the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) from 2004 to 2008. IR was assessed using the HOMA-IR. We modeled associations between coffee intake and NAFLD histologic severity using multiple logistic regression; and interactions between coffee and IR on NAFLD histology were explored.

Results

Among 782 participants, 38% (n = 295) were men, 12% (n = 97) were Latino, mean age (± standard deviation) was 48 ± 12 years. Me

SUBMITTER: Bambha K 

PROVIDER: S-EPMC4010559 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature