Evaluation of renal quantitative T2* changes on MRI following administration of ferumoxytol as a T2* contrast agent.

ABSTRACT:

Purpose

To evaluate the time-dependent changes in regional quantitative T2* maps of the kidney following intravenous administration of ferumoxytol.

Materials and methods

Twenty-four individuals with normal kidney function underwent T2*-weighted MRI of the kidney before, immediately after, and 48 hours after intravenous administration of ferumoxytol at a dose of 4 mg/kg (group A, n=12) or 6 mg/kg (group B, n=12). T2* values were statistically analyzed using two-tailed paired t-tests.

Results

In group A, the percentage changes from baseline to immediate post and baseline to 48 hours were 85.3% and 64.2% for the cortex and 90.8% and 64.6% for the medulla, respectively. In group B, the percentage changes from baseline to immediate post and baseline to 48 hours were 85.2%

SUBMITTER: Hedgire SS 

PROVIDER: S-EPMC4010631 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature