Autonomous and continuous adaptation of a bihormonal bionic pancreas in adults and adolescents with type 1 diabetes.

ABSTRACT:

Context

A challenge for automated glycemic control in type 1 diabetes (T1D) is the large variation in insulin needs between individuals and within individuals at different times in their lives.

Objectives

The objectives of the study was to test the ability of a third-generation bihormonal bionic pancreas algorithm, initialized with only subject weight; to adapt automatically to the different insulin needs of adults and adolescents; and to evaluate the impact of optional, automatically adaptive meal-priming boluses.

Design

This was a randomized controlled trial.

Setting

The study was conducted at an inpatient clinical research center.

Patients

Twelve adults and 12 adolescents with T1D participated in the study.

Interventions

Subjects in each age gr

SUBMITTER: El-Khatib FH 

PROVIDER: S-EPMC4010702 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature