Evidence of GnRH antagonist escape in obese women.

ABSTRACT:

Context

Assisted reproductive technology (ART) cycle cancelation rates are increased among overweight and obese women; however, the reasons for this are not completely clear. Premature luteinization due to inadequate endogenous gonadotropin suppression is a possibility for this higher risk of cancellation.

Objective

The objective of the study was to investigate the impact of female obesity on the pharmacokinetics of cetrorelix (GnRH antagonist).

Design

This was an interventional study.

Setting

The study was conducted at a university clinical and translational research center.

Participants

Regularly menstruating obese (n = 10) and normal-weight (n = 10) women participated in the study.

Interventions

A frequent blood sampling study was performed aft

SUBMITTER: Roth LW 

PROVIDER: S-EPMC4010706 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature