Metformin improves glucose effectiveness, not insulin sensitivity: predicting treatment response in women with polycystic ovary syndrome in an open-label, interventional study.

ABSTRACT:

Context

Although metformin is widely used to improve insulin resistance in women with polycystic ovary syndrome (PCOS), its mechanism of action is complex, with inconsistent effects on insulin sensitivity and variability in treatment response.

Objective

The aim of the study was to delineate the effect of metformin on glucose and insulin parameters, determine additional treatment outcomes, and predict patients with PCOS who will respond to treatment.

Design and setting

We conducted an open-label, interventional study at an academic medical center.

Subjects

Women with PCOS (n = 36) diagnosed by the National Institutes of Health criteria participated in the study.

Interventions

Subjects underwent fasting blood sampling, an IV glucose tolerance test, dual-en

SUBMITTER: Pau CT 

PROVIDER: S-EPMC4010712 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature