Distributed organization of a brain microcircuit analyzed by three-dimensional modeling: the olfactory bulb.

ABSTRACT: The functional consequences of the laminar organization observed in cortical systems cannot be easily studied using standard experimental techniques, abstract theoretical representations, or dimensionally reduced models built from scratch. To solve this problem we have developed a full implementation of an olfactory bulb microcircuit using realistic three-dimensional (3D) inputs, cell morphologies, and network connectivity. The results provide new insights into the relations between the functional properties of individual cells and the networks in which they are embedded. To our knowledge, this is the first model of the mitral-granule cell network to include a realistic representation of the experimentally-recorded complex spatial patterns elicited in the glomerular layer (GL) by natural o

SUBMITTER: Migliore M 

PROVIDER: S-EPMC4010739 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature