Using previously genotyped controls in genome-wide association studies (GWAS): application to the Stroke Genetics Network (SiGN).

ABSTRACT: Genome-wide association studies (GWAS) are widely applied to identify susceptibility loci for a variety of diseases using genotyping arrays that interrogate known polymorphisms throughout the genome. A particular strength of GWAS is that it is unbiased with respect to specific genomic elements (e.g., coding or regulatory regions of genes), and it has revealed important associations that would have never been suspected based on prior knowledge or assumptions. To date, the discovered SNPs associated with complex human traits tend to have small effect sizes, requiring very large sample sizes to achieve robust statistical power. To address these issues, a number of efficient strategies have emerged for conducting GWAS, including combining study results across multiple studies using meta-analys

SUBMITTER: Mitchell BD 

PROVIDER: S-EPMC4010766 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature