Type I IFN suppresses Cxcr2 driven neutrophil recruitment into the sensory ganglia during viral infection.

ABSTRACT: Infection induces the expression of inflammatory chemokines that recruit immune cells to the site of inflammation. Whereas tissues such as the intestine and skin express unique chemokines during homeostasis, whether different tissues express distinct chemokine profiles during inflammation remains unclear. With this in mind, we performed a comprehensive screen of the chemokines expressed by two tissues (skin and sensory ganglia) infected with a common viral pathogen (herpes simplex virus type 1). After infection, the skin and ganglia showed marked differences in their expression of the family of Cxcr2 chemokine ligands. Specifically, Cxcl1/2/3, which in turn controlled neutrophil recruitment, was up-regulated in the skin but absent from the ganglia. Within the ganglia, Cxcl2 expression and

SUBMITTER: Stock AT 

PROVIDER: S-EPMC4010892 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature