Mammalian fetal cardiac regeneration after myocardial infarction is associated with differential gene expression compared with the adult.

ABSTRACT:

Background

In adults, myocardial infarction (MI) results in a brisk inflammatory response, myocardium loss, and scar formation. We have recently reported the first mammalian large-animal model of cardiac regeneration after MI in fetal sheep. We hypothesize that the ability of the fetus to regenerate functional myocardium after MI is owing to differential gene expression regulating the response to MI in the fetus compared with the adult.

Methods

Myocardial infarction was created in adult (n=4) or early gestation fetal (n=4) sheep. Tissue was harvested after 3 or 30 days, and RNA was extracted for microarray, followed by principal component analysis and global gene expression analysis for the following gene ontology terms: response to wounding, inflammatory response, extracell

SUBMITTER: Zgheib C 

PROVIDER: S-EPMC4010943 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature