Lack of association between DRD2 and OPRM1 genotypes and adiposity.

ABSTRACT:

Background

Dopaminergic and opioid systems are both involved in food intake and appetite control. The dopamine D2 receptor gene (DRD2) and the μ-opioid receptor gene (OPRM1) therefore represent plausible candidates for association with obesity.

Objective

Previous studies of these variants have yielded inconsistent findings, which are likely due to insufficient statistical power. The aim of the current study was to determine whether, in a large population-based sample, there are associations between adiposity and (i) the A1 (T) allele of the Taq1A polymorphism (rs1800497) in DRD2 and (ii) the G allele of the A118G polymorphism (rs1799971) in OPRM1.

Study population

Annual clinic-based measures of body mass index (BMI) and waist circumference were taken from children (N

SUBMITTER: Hardman CA 

PROVIDER: S-EPMC4010970 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature