A dynamic cell adhesion surface regulates tissue architecture in growth plate cartilage.

ABSTRACT: The architecture and morphogenetic properties of tissues are founded in the tissue-specific regulation of cell behaviors. In endochondral bones, the growth plate cartilage promotes bone elongation via regulated chondrocyte maturation within an ordered, three-dimensional cell array. A key event in the process that generates this cell array is the transformation of disordered resting chondrocytes into clonal columns of discoid proliferative cells aligned with the primary growth vector. Previous analysis showed that column-forming chondrocytes display planar cell divisions, and the resulting daughter cells rearrange by ∼90° to align with the lengthening column. However, these previous studies provided limited information about the mechanisms underlying this dynamic process. Here we present ne

SUBMITTER: Romereim SM 

PROVIDER: S-EPMC4011088 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature