Radiogenomics of clear cell renal cell carcinoma: associations between CT imaging features and mutations.

ABSTRACT:

Purpose

To investigate associations between computed tomographic (CT) features of clear cell renal cell carcinoma (RCC) and mutations in VHL, PBRM1, SETD2, KDM5C, or BAP1 genes.

Materials and methods

The institutional review board approved this retrospective, hypothesis-generating study of 233 patients with clear cell RCC and waived the informed consent requirement. The study was HIPAA compliant. Three radiologists independently reviewed pretreatment CT images of all clear cell RCCs without knowledge of their genomic profile. One radiologist measured largest diameter and enhancement parameters of each clear cell RCC. Associations between CT features and mutations in VHL, PBRM1, SETD2, KDM5C, and BAP1 genes were tested by using the Fisher exact test. Associations between muta

SUBMITTER: Karlo CA 

PROVIDER: S-EPMC4011179 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature