Association between fibroblast growth factor 7 and the risk of chronic obstructive pulmonary disease.

ABSTRACT:

Aim

Fibroblast growth factor 7 (FGF7) is involved in a number of physiological and pathological processes, including lung disease. However, relatively little is known about the effect of FGF7 gene polymorphisms on chronic obstructive pulmonary disease (COPD) susceptibility. This study aimed to investigate the association between FGF7 polymorphisms with COPD susceptibility in a Chinese Han population.

Methods

We conducted a case-control study of 279 COPD patients and 367 age- and gender-distribution-matched control subjects. The tagging SNPs rs10519225 and rs7170426 in FGF7 were genotyped by SNaPshot. The associations of each SNP genotype and haplotype constructed by these loci with COPD were analyzed.

Results

A multivariate analysis showed that rs10519225 was signific

SUBMITTER: Xu SC 

PROVIDER: S-EPMC4011325 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature