The effect of lowering LDL cholesterol on vascular access patency: post hoc analysis of the Study of Heart and Renal Protection.

ABSTRACT:

Background and objectives

Reducing LDL cholesterol (LDL-C) with statin-based therapy reduces the risk of major atherosclerotic events among patients with CKD, including dialysis patients, but the effect of lowering LDL-C on vascular access patency is unclear.

Design, setting, participants, & measurements

The Study of Heart and Renal Protection (SHARP) randomized patients with CKD to 20 mg simvastatin plus 10 mg ezetimibe daily versus matching placebo. This study aimed to explore the effects of treatment on vascular access occlusive events, defined as any access revision procedure, access thrombosis, removal of an old dialysis access, or formation of new permanent dialysis access.

Results

Among 2353 SHARP participants who had functioning vascular access at randomizatio

SUBMITTER: Herrington W 

PROVIDER: S-EPMC4011457 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature