Genetic variations within metalloproteinases impact on the prophylaxis of depressive phases in bipolar patients.

ABSTRACT:

Background

The genetic background of the antidepressant response to pharmacological treatment in bipolar disorder (BD) remains elusive. This issue is of primary relevance in that the depressive phases of BD are difficult to treat and they are associated with suicide.

Aim

We investigated the role of a set of genetic variations (single-nucleotide polymorphisms) harbored by matrix metalloproteinases (MMPs) as predictors of response to treatment in depressed BD patients.

Methods

654 BD patients from the publicly available Systematic Treatment Enhancement Program for Bipolar Disorder study were investigated. The outcome was the number of depressive events corrected by the number of times patients were assessed. Clinical and sociodemographic variables were tested as possibl

SUBMITTER: Drago A 

PROVIDER: S-EPMC4011491 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature