Regional increases of cortical thickness in untreated, first-episode major depressive disorder.

ABSTRACT: The large majority of structural MRI studies of major depressive disorder (MDD) investigated volumetric changes in chronic medicated patients in whom course of illness and treatment effects may impact anatomic measurements. Further, in few studies, separate measurements of cortical thickness and surface area have been performed that reflect different neurobiological processes regulated by different genetic mechanisms. In the present study, we investigated both cortical thickness and surface area in first-episode, treatment-naïve, mid-life MDD to elucidate the core pathophysiology of this disease and its early impact on the brain. We observed increased cortical thickness in the right hemisphere, including medial orbitofrontal gyrus, pars opercularis, rostral middle frontal gyrus and suprama

SUBMITTER: Qiu L 

PROVIDER: S-EPMC4012282 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature