Designing nanogel carriers for antibacterial applications.

ABSTRACT: We have developed a novel and simple synthesis route to create nanosized (∼5nm) silver nanoparticles (Ag NPs) embedded in a biocompatible nanogel (NG) comprising degradable, natural polymers, namely dextran and lysozyme. In this study, we prepared hybrid nanogels with varying lysozyme content, evaluated their potential to reduce Ag NPs in situ (using ultraviolet-visible spectroscopy, cryo-transmission electronic microscopy, thermogravimetric analysis and Fourier transform infrared spectroscopy) and determined their antibacterial properties against Escherichia coli and Staphylococcus aureus. Lysozyme was found to enhance nucleation and stabilization of Ag NPs while limiting their growth. As lysozyme concentration increased, larger nanogels with greater loading of smaller Ag NPs were obtaine

SUBMITTER: Coll Ferrer MC 

PROVIDER: S-EPMC4012329 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature