The prelimbic cortex and subthalamic nucleus contribute to cue-guided behavioral switching.

ABSTRACT: Frontal cortex-basal ganglia circuitry supports behavioral switching when a change in outcome information is used to adapt response patterns. Less is known about whether specific frontal cortex-basal ganglia circuitry supports behavioral switching when cues signal that a change in response patterns should occur. The present experiments investigated whether the prelimbic cortex and subthalamic nucleus in male Long-Evans rats supports cue-guided switching in a conditional discrimination test. Rats learned in a cross-maze that a start arm cue (black or white) signaled which of two maze arms to enter for a food reward. The cue was switched every 3-6 trials. Baclofen and muscimol infused into the prelimbic cortex significantly impaired performance by increasing switch trial errors, as well as t

SUBMITTER: Baker PM 

PROVIDER: S-EPMC4012559 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature