Androgen receptor splice variants determine taxane sensitivity in prostate cancer.

ABSTRACT: Prostate cancer growth depends on androgen receptor signaling. Androgen ablation therapy induces expression of constitutively active androgen receptor splice variants that drive disease progression. Taxanes are a standard of care therapy in castration-resistant prostate cancer (CRPC); however, mechanisms underlying the clinical activity of taxanes are poorly understood. Recent work suggests that the microtubule network of prostate cells is critical for androgen receptor nuclear translocation and activity. In this study, we used a set of androgen receptor deletion mutants to identify the microtubule-binding domain of the androgen receptor, which encompasses the DNA binding domain plus hinge region. We report that two clinically relevant androgen receptor splice variants, ARv567 and ARv7, di

SUBMITTER: Thadani-Mulero M 

PROVIDER: S-EPMC4012562 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature