Urine lipoarabinomannan testing for diagnosis of pulmonary tuberculosis in children: a prospective study.

ABSTRACT:

Background

Urine tests for mycobacterial lipoarabinomannan might be useful for point-of-care diagnosis of tuberculosis in adults with advanced HIV infection, but have not been assessed in children. We assessed the accuracy of urine lipoarabinomannan testing for the diagnosis of pulmonary tuberculosis in HIV-positive and HIV-negative children.

Methods

We prospectively recruited children (aged ≤ 15 years) who presented with suspected tuberculosis at a primary health-care clinic and paediatric referral hospital in South Africa, between March 1, 2009, and April 30, 2012. We assessed the diagnostic accuracy of urine lipoarabinomannan testing with lateral fl ow assay and ELISA, with mycobacterial culture of two induced sputum samples as the reference standard. Positive cultures we

SUBMITTER: Nicol MP 

PROVIDER: S-EPMC4012567 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature