Persistence and complex evolution of fluoroquinolone-resistant Streptococcus pneumoniae clone.

ABSTRACT: Prolonged outbreaks of multidrug-resistant Streptococcus pneumoniae in health care facilities are uncommon. We found persistent transmission of a fluroquinolone-resistant S. pneumoniae clone during 2006-2011 in a post-acute care facility in Israel, despite mandatory vaccination and fluoroquinolone restriction. Capsular switch and multiple antimicrobial nonsusceptibility mutations occurred within this single clone. The persistent transmission of fluoroquinolone-resistant S. pneumoniae during a 5-year period underscores the importance of long-term care facilities as potential reservoirs of multidrug-resistant streptococci.

SUBMITTER: Ben-David D 

PROVIDER: S-EPMC4012785 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature