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Bovine leukemia virus DNA in human breast tissue.

ABSTRACT: Bovine leukemia virus (BLV), a deltaretrovirus, causes B-cell leukemia/lymphoma in cattle and is prevalent in herds globally. A previous finding of antibodies against BLV in humans led us to examine the possibility of human infection with BLV. We focused on breast tissue because, in cattle, BLV DNA and protein have been found to be more abundant in mammary epithelium than in lymphocytes. In human breast tissue specimens, we identified BLV DNA by using nested liquid-phase PCR and DNA sequencing. Variations from the bovine reference sequence were infrequent and limited to base substitutions. In situ PCR and immunohistochemical testing localized BLV to the secretory epithelium of the breast. Our finding of BLV in human tissues indicates a risk for the acquisition and proliferation of this virus in humans. Further research is needed to determine whether BLV may play a direct role in human disease.

SUBMITTER: Buehring GC

PROVIDER: S-EPMC4012802 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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Bovine leukemia virus DNA in human breast tissue.

Buehring Gertrude Case GC Shen Hua Min HM Jensen Hanne M HM Choi K Yeon KY Sun Dejun D Nuovo Gerard G

Emerging infectious diseases 20140501 5

Bovine leukemia virus (BLV), a deltaretrovirus, causes B-cell leukemia/lymphoma in cattle and is prevalent in herds globally. A previous finding of antibodies against BLV in humans led us to examine the possibility of human infection with BLV. We focused on breast tissue because, in cattle, BLV DNA and protein have been found to be more abundant in mammary epithelium than in lymphocytes. In human breast tissue specimens, we identified BLV DNA by using nested liquid-phase PCR and DNA sequencing. ...[more]

PMID: 24750974

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Bovine leukemia viral DNA found on human breast tissue is genetically related to the cattle virus.

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Bovine leukemia virus DNA associated with breast cancer in women from South Brazil.

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Bovine leukemia virus discovered in human blood.

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No evidence of bovine leukemia virus proviral DNA and antibodies in human specimens from Japan.

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Investigation of the bovine leukemia virus proviral DNA in human leukemias and lung cancers in Korea.

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Molecular investigation of possible relationships concerning bovine leukemia virus and breast cancer.

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